egfr gene การใช้

• EGFR-TKI's have been found to be active against variants exhibiting certain mutations in the EGFR gene.
• In 2014 in the TRANSCOG study ( Petty et al . ), demonstrated gefitinib was effective in esophageal cancer patients whose tumours harboured additional copies of the EGFR gene.
• Abnormal duplication of the EGFR gene is a relatively infrequent phenomenon in SCL ( > / = 4 copies in > / = 40 % of cells in 5 / 22)